Methods Citations. Results Citations. Topics from this paper. Citation Type. Has PDF. Publication Type. More Filters. Cytochrome P 1A1 opens up to new substrates. Microbial Cytochromes P Applications of microbial cytochrome P enzymes in biotechnology and synthetic biology. Cytochrome Pmediated metabolic engineering: current progress and future challenges. Controlling substrate specificity and product regio- and stereo-selectivities of P enzymes without mutagenesis. Engineering cytochrome P biocatalysts for biotechnology, medicine and bioremediation.
Monooxygenases as biocatalysts: Classification, mechanistic aspects and biotechnological applications. Deletion of microsomal cytochrome b5 profoundly affects hepatic and extrahepatic drug metabolism.
Breakthrough in P bioelectrochemistry and future perspectives. Enzyme systems for biodegradation of polychlorinated dibenzo-p-dioxins. Cytochromes P in nanodiscs. Targeting of the highly conserved threonine residue of cytochromes P 2B family during mechanism-based inactivation by aryl acetylenes. Structural and biochemical characterization of Mycobacterium tuberculosis CYP evidence for multiple cholesterol hydroxylase activities in a human pathogen. The interaction of microsomal cytochrome P 2B4 with its redox partners, cytochrome P reductase and cytochrome b 5.
Structure of the quinoline N-hydroxylating cytochrome P RauA, an essential enzyme that confers antibiotic activity on aurachin alkaloids. The evolution of our understanding of endo-xenobiotic crosstalk and cytochrome P regulation and the therapeutic implications. Streptomyces cytochromes P applications in drug metabolism. Heterologous expression of the isopimaric acid pathway in Nicotiana benthamiana and the effect of N-terminal modifications of the involved cytochrome P enzyme.
Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P in the fumagillin pathway. Chemomimetic biocatalysis: exploiting the synthetic potential of cofactor-dependent enzymes to create new catalysts. Electron donation to an archaeal cytochrome P is enhanced by PCNA-mediated selective complex formation with foreign redox proteins.
Overcoming heterologous protein interdependency to optimize Pmediated Taxol precursor synthesis in Escherichia coli. Enzyme promiscuity: using a P enzyme as a carbene transfer catalyst. Applications of microbial cytochrome P enzymes in biotechnology and synthetic biology.
CYPdiverse structures, functions and roles in an intriguing family of enzymes in Streptomyces. Human Plike oxidation of diverse proton pump inhibitor drugs by 'gatekeeper' mutants of flavocytochrome P BM3.
Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol. Lyophilization conditions for the storage of monooxygenases. Cytochrome Pmediated metabolic engineering: current progress and future challenges. Structural basis for the 4'-hydroxylation of diclofenac by a microbial cytochrome P monooxygenase. How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion.
Bifunctional CYP81AA proteins catalyse identical hydroxylations but alternative regioselective phenol couplings in plant xanthone biosynthesis. Application of nanodisc technology for direct electrochemical investigation of plant cytochrome Ps and their NADPH P oxidoreductase.
More than just recruitment: the X-domain influences catalysis of the first phenolic coupling reaction in A biosynthesis by Cytochrome P StaH. Cytochrome P structure-function: insights from molecular dynamics simulations.
An efficient light-driven P BM3 biocatalyst. Fenton chemistry at aqueous interfaces. Tools of pathway reconstruction and production of economically relevant plant secondary metabolites in recombinant microorganisms. Controlling substrate specificity and product regio- and stereo-selectivities of P enzymes without mutagenesis. Catalyst design in oxidation chemistry; from KMnO4 to artificial metalloenzymes.
Photosynthetic fuel for heterologous enzymes: the role of electron carrier proteins. Recent studies have provided the first definitive characterization of the transient reaction cycle intermediate compound I responsible for the majority of P oxidative reactions. This major advance comes at a time when P engineering has facilitated the elucidation of several mammalian P structures and generated P variants with novel substrate specificity and reactivity.
This review describes recent advances in P research and the ramifications for biotechnological and biomedical exploitation of these enzymes. What makes a P tick? N2 - The cytochromes P Ps are probably nature's most versatile enzymes in terms of both their vast substrate range and the diverse types of molecular transformations performed across the P enzyme superfamily.
AB - The cytochromes P Ps are probably nature's most versatile enzymes in terms of both their vast substrate range and the diverse types of molecular transformations performed across the P enzyme superfamily. Overview Fingerprint.
Abstract The cytochromes P Ps are probably nature's most versatile enzymes in terms of both their vast substrate range and the diverse types of molecular transformations performed across the P enzyme superfamily. Access to Document
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