The kynurenine pathway in brain tumor pathogenesis. Tumor metabolism as modulator of immune response and tumor progression. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy.
Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism. Indoleamine 2,3-dioxygenase and tumor-induced tolerance. Beyond immunosuppression: reconsidering indoleamine 2,3-dioxygenase as a pathogenic element of chronic inflammation. The aryl hydrocarbon receptor: a perspective on potential roles in the immune system.
Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase. Related Papers. Figure 1 Infrared thermal emitter. Liu et al. Issue Date : 13 October Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. BMC Cancer Scientific Reports Oncogene Advanced search. Skip to main content Thank you for visiting nature.
Subjects Cancer Cell invasion Cell signalling Immunology. Access through your institution. Buy or subscribe. Change institution. Rent or Buy article Get time limited or full article access on ReadCube. Figure 1: The kynurenine pathway of cancer invasion and immune escape. References 1 Opitz, C. Author information Affiliations George C. Prendergast Authors George C. Prendergast View author publications. Rights and permissions Reprints and Permissions.
About this article Cite this article Prendergast, G. Copy to clipboard. Further reading What is the prospect of indoleamine 2,3-dioxygenase 1 inhibition in cancer? Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium LC3.
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