Number of in-hospital mortality during the 30 days following inclusion. Number of patients transferred to intensive care unit during the day follow-up. Number of days without mechanical ventilation during the 30 days following inclusion.
Hospital length of stay during the 30 days following inclusion. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Life-threatening presentation expected to lead to possible imminent death based on provider assessment.
Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials. More Information. National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services.
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Allocation concealment is uncertain. The subjects were assessed clinically at baseline, by telephone at day 4, and again clinically at days 10 and Analysis of data was done on an intention-to-treat basis.
Secondary outcomes were adverse reaction to medication and compliance. In the intention-to-treat population patients , clinical success at 28 days was equivalent among AZM-3 However, keep in mind that antibiotics in general do not provide a clinically meaningful advantage when compared with placebo.
Azithromycin is well tolerated, and patients are more likely to complete a 3-day course than a day one. Researchers have known about these drug actions, but until now there had been no large study looking at the risk of severe low blood pressure among patients on calcium channel blockers and macrolides. For their study, Juurlink and his colleagues looked at medical records for more than , Ontario residents age 66 and up who were on a calcium channel blocker at some point between and During that time, 7, were hospitalized for severe drops in blood pressure.
Of those patients, had been on a macrolide antibiotic in the week before their hospitalization. Clarithromycin was tied to a nearly four-fold increase. Because of the study design, Juurlink said he could not give a precise figure for the absolute risk of severe hypotension from the drug combination.
Still, Juurlink added, it appears to be an avoidable risk. As for other classes of blood pressure drugs -- like ACE inhibitors and beta-blockers -- they do not seem to be susceptible to the effects of the two antibiotics, according to Juurlink. The current study focused on older adults because they are most vulnerable to the consequences of drops in blood pressure. They could, for instance, get dizzy enough to fall and break a hip.
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